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Lowell Stone starting in 1980, and used and refined it over the next 25 years. The model subsequently has been described as "an elegant in vivo model of sudden cardiac death" by cardiologist Michel de Lorgeril et al. and "a highly reliable canine model of sudden cardiac death" by physiologist Alexander Leaf et al. The model is described in Springer's handbook of reliable procedures for testing the potential effects of new drug candidates in the antiarrhythmic section. In the procedure, the left main anterior coronary artery is surgically blocked and a hydraulic cuff is placed around the left circumflex coronary artery, allowing the artery to be blocked on demand. Experiments proceed after a month of recovery and treadmill training. Under stress from exercise combined with the blocking of the arteries, 50–60% of dogs enter fatal ventricular fibrillation within 2 minutes. These dogs are labeled susceptible, while the other 40–50% are labeled resistant. Dogs that enter VF are defibrillated, allowing for repeated study of the same animals. Over time, initial results (fibrillation or no fibrillation) have proven to be 92% reproducible, allowing for precise testing of potential antiarrhythmic agents. This model of sudden cardiac death has "yielded important insights" into ischaemic heart disease. The initial study using the technique, published in 1982, found that decreased baroreflex sensitivity was associated with increased risk for ventricular fibrillation. This marked the first time an autonomic response was seen as having prognostic value. The same association was demonstrated in humans by Kleiger et al. in 1987 and "definitively" demonstrated in dogs in 1988 by Schwartz, Billman, et al. On the basis of these findings, a large clinical study (Autonomic Tone and Reflexes After MI), was conducted. The 1,284 patient study "fully confirmed" baroreflex sensitivity as a valid predictor of sudden and non-sudden death after myocardial infarction (MI). Billman's model of SCD has also shown that sudden death is not a direct function of the degree of a myocardial infarction and that baroreflex gain declines during MI. Resistant dogs show a reduced heart rate during ischemia, while susceptible dogs show increased heart rate (beyond that induced by the exercise). Reviewing the findings, physiologist Dwain L. Eckberg wrote that the model "seems to be extremely relevant" to human patients at risk for sudden cardiac death. Cocaine and heart function According to a 1990 review article by Billman, cocaine has two primary circulatory effects – increased sympathetic stimulation and cardiac ion channel inhibition – that lead to a variety of heart problems. The drug also causes increased heart rate and blood pressure. In a 1995 review article, he said resulting secondary effects include arrhythmia, coronary vasospasm, myocardial infarction, and ventricular fibrillation. Omega-3 fatty acids In 1994, Billman used his model of SCD to test the ability of omega-3 polyunsaturated

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